Camelon 125

Camelon 125

methylprednisolone

Manufacturer:

Caprifarmindo

Marketer:

Caprifarmindo
Concise Prescribing Info
Contents
Methylprednisolone
Indications/Uses
Abnormality of adrenocorticoid function, allergic, collagen, dermatological, GI, haematologic, ophth, rheumatic disorders; hepatic, neurologic disease; hypercalcemia associated w/ neoplasm (or sarcoidosis), non-rheumatoid inflammation, nephrotic syndrome; neoplastic & resp diseases; neurotrauma: Spinal cord injury; pericarditis, nasal polyps, shock therapy caused by adrenocortical insufficiency, non-suppurative thyroiditis. Treatment of trichinosis. Prophylaxis & treatment of organ transplant rejection.
Dosage/Direction for Use
Adult & adolescent 10-40 mg IM or IV, repeated as needed. High-dose 30 mg/kg IV over at least 30 min, may be repeated every 4-6 hr as needed. Acute exacerbations of multiple sclerosis 160 mg IM or IV daily for 1 wk, followed by 64 mg every other day for 1 mth. Acute spinal cord injury 30 mg IV over 15 min, followed in 45 min by continuous infusion of 5.4 mg/kg/hr, for 23 hr. Adjunctive treatment in AIDS-associated Pneumocystis carinii 30 mg IV twice daily on days 1-5, 30 mg once on days 6-10, & 15 mg once daily on days 11-21. Childn Adrenocortical insufficiency 117 mcg (0.117 mg)/kg or 3.33 mg/m2 in 3 divided doses every 3rd day; or 39-58.5 mcg (0.039-0.0585 mg)/kg or 1.11-1.66 mg/m2 once a day. Acute spinal cord injury 30 mg/kg IV over 15 min, followed in 45 min by a continuous infusion of 5.4 mg/kg/hr for 23 hr. Other indications 139-835 mcg (0.139-0.835 mg)/kg IM or 4.16-25 mg/m2 every 12-24 hr. Adjunctive treatment in AIDS-associated Pneumocystis carinii Childn >13 yr Usual adult & adolescent dose.
Contraindications
Hypersensitivity. Systemic fungal infections, long-term use in patients w/ duodenal & peptic ulcer, severe osteoporosis, herpes; history of psychosis; recent immunization. Premature infant.
Special Precautions
Patient should not be vaccinated against small-pox or other immune vaccines especially on high doses. Close observation is necessary in patients w/ latent TB or tuberculin reactivity. Not recommended in patients w/ ocular herpes simplex. May mask some signs of infection & new infections may appear during use. Long-term treatment may decrease body's stamina against infectious diseases. Not recommended in pregnant women & nursing mothers. Childn; if necessary, infant growth should be monitored. May cause acute pancreatitis followed by pancreatic destruction in childn. Elderly.
Adverse Reactions
Adrenocortical insufficiency; musculoskeletal, ocular, endocrine, GIT, nervous system & dermatological effects, fluid & electrolyte disturbances. Sudden discontinuation produces nausea, vomiting, loss of appetite, lethargy, headache, fever, joint pain, desquamation, myalgia, wt loss, hypotension, hyper- or hypopigmentation, SC & cutaneous atrophy, sterile abscess, anaphylactic reaction, cardiac arrest, bronchospasm, cardiac arrhythmias.
Drug Interactions
Hepatic microsomal enzyme inducers may increase glucocorticoid metabolism. Concomitant administration w/ ulcerogenic drugs eg, indomethacin may increase risk of GIT ulceration. May result in GI risk, bleeding w/ NSAIDs or other antirheumatics. K-depleting diuretics (eg, thiazides, furosemide, ethacrynic acid) & other drugs that deplete K. Anti-cholinesterase agents can produce weakness in patients w/ myasthenia gravis. May cause reduction responses to toxoids & live or inactivated vaccines.
MIMS Class
Corticosteroid Hormones
ATC Classification
H02AB04 - methylprednisolone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
Presentation/Packing
Form
Camelon 125 powd for inj 125 mg
Packing/Price
(+ amp (2 mL solvent)) 1's (Rp87,000/boks)
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